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Author: Dana Bartlett, BSN, MSN, MA, CSPI
(Click author's name for bio)

CE: 2.5 hours Pharmacology: 2.5 hours
Rated 4.8 out of 5.0 based on 384 reviews

Course Summary

Thiothixene is a typical antipsychotic that has a labeled use for the treatment of patients who have schizophrenia and is used off-label for the treatment of agitation and psychosis caused by dementia. Thiothixene belongs to the class of drugs known as thioxanthenes with anticholinergic properties and was introduced into the market in 1967 under the trade name Navane and was reported by Leung (2015) to be more potent than chlorpromazine. The use of thiothixene has significantly declined in recent decades with the advent of the newer atypical antipsychotics however continues to be manufactured and used in many countries worldwide.

Course Format


Course Syllabus

I.              Introduction

II.           Pharmacology Profile

1.           Category

2.           Mechanism of Action

3.           Labeled Uses

4.           Off-label Uses

5.           Unlabeled Using

6.           Dosing and Administration

7.           Available Forms

8.           Dosing Adjustment: Geriatric Patients

9.           Dosing Adjustment: Hepatic Impairment

10.                 Dosing Adjustment: Renal Impairment

11.                 US Boxed Warning

12.                 Adverse Effects

13.                 Warnings and Precautions

14.                 Pregnancy and Breastfeeding

15.                 Drug-Drug Interactions

III.         Clinical Pearls: Thiothixene

IV.          Thiothixene Overdose

V.            Case Study: Thiothixene

1.            Discussion

VI.          Summary


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