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Author: Dana Bartlett, BSN, MSN, MA, CSPI
(Click author's name for bio)

CE: 2.5 hours Pharmacology: 2.5 hours
Rated 4.7 out of 5.0 based on 860 reviews

Course Summary

Mirtazapine is an antidepressant with a labeled use for the treatment of major depressive disorder. Serotonin release (blocking a-2 autoreceptors and heteroreceptors, selectively antagonizing the serotonin 5-HT2 and 5-HT3 receptors in the central and peripheral nervous system) is reportedly increased by mirtazapine use. Clinicians should monitor patients for side effects of mirtazapine use, and during drug tapering. Rapid discontinuation of mirtazapine should be avoided to prevent the risk of discontinuation syndrome.

Course Format


Course Syllabus

I.              Introduction

II.           Pharmacological Profile

1.         Drug Category

2.         Mechanism of Action

3.         Labeled Uses

4.         Off-Label Uses

5.         Dosing

6.         Available Forms

7.         Dosing Adjustment: Geriatric Patients

8.         Dosing Adjustment: Hepatic Impairment

9.         Dosing Adjustment: Renal Impairment

10.     US Boxed Warning

11.     Contraindications

12.     Adverse Effects

13.     Warnings and Precautions

14.     Pregnancy and Breastfeeding

15.     Drug-drug Interactions

III.        Clinical Pearls: Mirtazapine

IV.         Mirtazapine Overdose

V.            Case Study: Mirtazapine

1.   Discussion

VI.         Summary


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