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Author: Dana Bartlett, BSN, MSN, MA, CSPI
(Click author's name for bio)

CE: 2.5 hours Pharmacology: 2.5 hours
Rated 4.8 out of 5.0 based on 428 reviews

Course Summary

Loxapine is an antipsychotic that is used for the treatment of patients who have schizophrenia. It is known as a typical antipsychotic with high-potency effect, typically used in lower doses and titrated to effect. Loxapine has low activity at histaminic and muscarinic receptors so anticholinergic effects and sedation are less likely to occur, as compared to antipsychotics with low-potency effect. Loxapine use has been revisited in the literature most recently in terms of its usefulness for acute agitation and aggression for both child/adolescents and adults. More research however is needed on the potential benefits and risks of loxapine use in chronically mentally ill individuals or those with an acute, severe state of agitation and aggression, which may constitute a psychiatric emergency.

Course Format


Course Syllabus

I.              Introduction

II.           Pharmacological Profile

1.         Drug Category

2.         Mechanism of Action

3.         Labeled Uses

4.         Off-Label Uses

5.         Dosing

6.         Available Forms

7.         Dosing Adjustment: Geriatric Patients

8.         Dosing Adjustment: Hepatic Impairment

9.         Dosing Adjustment: Renal Impairment

10.     US Boxed Warning

11.     Contraindications

12.     Adverse Effects

13.     Warnings and Precautions

14.     Pregnancy and Breastfeeding

15.     Drug-drug Interactions

III.        Clinical Pearls: Loxapine

IV.         Loxapine Overdose

V.            Case Study: Loxapine

1.   Discussion

VI.         Summary


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