Course Summary

Expiration Date: 12/01/2027

Thiazide and thiazide-like diuretics are one of four first-line drug classes recommended for treating primary hypertension in specific patient populations. Due to their proven efficacy in lowering blood pressure, they remain a preferred choice for hypertension management, even in patients with comorbid conditions such as diabetes. Although the frequency of adverse effects is not always specified in the prescribing information, clinicians should be aware that these diuretics can lower blood pressure, reduce intravascular volume, and potentially alter electrolyte levels, glucose, lipids, and uric acid. Consequently, monitoring for adverse effects such as electrolyte imbalances, hyperglycemia, hyperlipidemia, and exacerbation of conditions like gout is crucial in patients receiving thiazide therapy.

Course Format

Homestudy

Course Syllabus

  • Introduction
  • Pharmacological Profile
    • Mechanism of Action
    • Indications, Dosing, and Administration
    • Administration
    • Hepatic and Renal Impairment: Dosing Adjustments
    • Geriatric Patients: Dosing Adjustments
  • Clinical Applications
    • Hypertension Management
    • Heart failure
    • Edema management
    • Osteoporosis
    • Diabetes insipidus
    • Nephrolithiasis prevention
  • Adverse Effects and Contraindications
    • Contraindications
  • Pregnancy and Breastfeeding
    • Breastfeeding
  • Drug-Drug Interactions
    • Monitoring
  • Toxicity/Overdose
    • Long-Term Management
  • Clinical Pearls
    • Thiazide Diuretics and Bone Health
    • Thiazides and Increased Risk for Gout
    • Efficacy Limitations in Renal Impairment
    • Thiazide Efficacy and Place in Therapy
  • Case Study: Severe Hyponatremia
  • Summary

Authors

Richard Daniels, PharmD, BCPS

Richard “Cole” Daniels earned his Doctor of Pharmacy(PharmD) from the Skaggs School of Pharmacy at the University of Montana in 2018. Throughout pharmacy school he completed a 3-year internship at Community Medical Center in Missoula, Montana in which he gained valuable experience in an acute care setting. Cole currently serves as a psychiatric clinical staff pharmacist at the Montana State Hospital. He has over 11 years of pharmacy experience having worked in several settings including retail, acute care, and inpatient psychiatric care. Cole has a diverse set of interests. However, acute care medicine, infectious disease, pain management, and asthma/COPD are a primary focus of his at the Montana State Hospital. He obtained board certification as a certified pharmacotherapy specialist in the Spring of 2022.

Elisabeth Gordon, BScPharm, RPh

Elisabeth Gordon earned her BSc(Pharm) from the University of British Columbia in 2004. After graduation, she worked in community retail pharmacies on Vancouver Island, before returning to her rural hometown of Salmon Arm. In 2016 and 2017, Elisabeth trained with Pallium Canada and Victoria Hospice to enhance her knowledge of end-of-life-care and palliative services. She is a volunteer medical supervisor for T1DOutreach, a peer support platform for adults living with type 1 diabetes, and a member of a Canadian peer support group for adults living with Birdshot Uveitis. Elisabeth enjoys working in a small, fast-paced rural pharmacy where she brings compassion and empathy to her everyday practice.