Course Summary

Expiration Date: 05/18/2028

Perphenazine is a first-generation antipsychotic used in the treatment of schizophrenia and severe nausea and vomiting. While less commonly prescribed today, it remains a valuable option in select cases, particularly when second-generation antipsychotics are ineffective or contraindicated. This course reviews perphenazine’s pharmacology, clinical indications, dosing, and safety considerations. Recent evidence and guideline-based insights are discussed, highlighting its potential role in psychotic depression and treatment-resistant conditions.

Course Format

Homestudy

Course Syllabus

  • Introduction
  • Pharmacological Overview
  • Therapeutic Applications in Psychiatry and Medicine
    • Schizophrenia
    • Severe Nausea and Vomiting
    • Off-Label Psychiatric Uses
    • Typical Dosage and Administration
  • Special Population Considerations
    • Hepatic & Renal Dosing
    • Pregnancy and Lactation
    • Use in Older Adults and Dementia
    • Use in Adolescents and Pediatrics
  • Contraindications and Adverse Effects
  • Toxicity and Monitoring
  • RX Journal Club: Perphenazine Evidence Update
    • Introduction
    • Study Objective
    • Methods
    • Key Findings
    • Discussion
    • Current Treatment Guidelines
    • Role of Perphenazine
    • Study Limitations
    • Clinical Implications & Future Directions
    • Journal Club Conclusion
  • Course Summary

Authors

Richard Daniels, PharmD, BCPS

Richard “Cole” Daniels earned his Doctor of Pharmacy(PharmD) from the Skaggs School of Pharmacy at the University of Montana in 2018. Throughout pharmacy school he completed a 3-year internship at Community Medical Center in Missoula, Montana in which he gained valuable experience in an acute care setting. Cole currently serves as a psychiatric clinical staff pharmacist at the Montana State Hospital. He has over 11 years of pharmacy experience having worked in several settings including retail, acute care, and inpatient psychiatric care. Cole has a diverse set of interests. However, acute care medicine, infectious disease, pain management, and asthma/COPD are a primary focus of his at the Montana State Hospital. He obtained board certification as a certified pharmacotherapy specialist in the Spring of 2022.

Elisabeth Gordon, BScPharm, RPh

Elisabeth Gordon earned her BSc(Pharm) from the University of British Columbia in 2004. After graduation, she worked in community retail pharmacies on Vancouver Island, before returning to her rural hometown of Salmon Arm. In 2016 and 2017, Elisabeth trained with Pallium Canada and Victoria Hospice to enhance her knowledge of end-of-life-care and palliative services. She is a volunteer medical supervisor for T1DOutreach, a peer support platform for adults living with type 1 diabetes, and a member of a Canadian peer support group for adults living with Birdshot Uveitis. Elisabeth enjoys working in a small, fast-paced rural pharmacy where she brings compassion and empathy to her everyday practice.