Course Summary

Expiration Date: 12/30/2027

Iloperidone is a second-generation atypical antipsychotic primarily indicated for the treatment of schizophrenia. It is also used off-label to manage agitation and psychosis associated with dementia. This article provides a comprehensive overview of iloperidone’s pharmacological profile, including its approved and off-label uses and associated warnings, precautions, and contraindications. Key insights and practical considerations are further explored in the clinical pearls section. Additionally, the article reviews the management of iloperidone overdose and concludes with a detailed case study to illustrate its clinical application.

Course Format

Homestudy

Course Syllabus

  • Introduction
  • Pharmacological Profile
    • Absorption, Distribution, Metabolism, and Excretion (ADME)
    • Indications and Clinical Applications
    • Initial and Maintenance Dosing
    • Special Populations
  • Current Recommendations for Iloperidone Use
    • Schizophrenia
    • Bipolar I Disorder
  • Iloperidone Warnings, Precautions, and Adverse Effects
    • Pregnancy and Breastfeeding
    • Adverse Effects by Body System
    • Severe Adverse Effects
  • Clinically Relevant Drug-Drug Interactions
  • Monitoring Guidelines of Iloperidone Use: Risks and Benefits
    • Special Monitoring Considerations
    • Frequency of Monitoring: Baseline and Follow-up
  • Toxicity and Medical Management
    • Clinical Presentation
    • Level of Severity and Neuroleptic Malignant Syndrome
    • ABC Protocol and Complications of Toxicity
  • Interprofessional Health Team Approach
  • Case Study: Atypical Neuroleptic Malignant Syndrome
  • Associated with Iloperidone Administration
  • Clinical Pearls
  • Summary

Authors

Richard Daniels, PharmD, BCPS

Richard “Cole” Daniels earned his Doctor of Pharmacy(PharmD) from the Skaggs School of Pharmacy at the University of Montana in 2018. Throughout pharmacy school he completed a 3-year internship at Community Medical Center in Missoula, Montana in which he gained valuable experience in an acute care setting. Cole currently serves as a psychiatric clinical staff pharmacist at the Montana State Hospital. He has over 11 years of pharmacy experience having worked in several settings including retail, acute care, and inpatient psychiatric care. Cole has a diverse set of interests. However, acute care medicine, infectious disease, pain management, and asthma/COPD are a primary focus of his at the Montana State Hospital. He obtained board certification as a certified pharmacotherapy specialist in the Spring of 2022.

Elisabeth Gordon, BScPharm, RPh

Elisabeth Gordon earned her BSc(Pharm) from the University of British Columbia in 2004. After graduation, she worked in community retail pharmacies on Vancouver Island, before returning to her rural hometown of Salmon Arm. In 2016 and 2017, Elisabeth trained with Pallium Canada and Victoria Hospice to enhance her knowledge of end-of-life-care and palliative services. She is a volunteer medical supervisor for T1DOutreach, a peer support platform for adults living with type 1 diabetes, and a member of a Canadian peer support group for adults living with Birdshot Uveitis. Elisabeth enjoys working in a small, fast-paced rural pharmacy where she brings compassion and empathy to her everyday practice.