Course Summary

Iloperidone (Fanapt®) is a second-generation atypical antipsychotic that is used for the treatment of schizophrenia. The drug acts at dopamine and serotonin receptor sites, has a low affinity for histamine receptors, and it does not bind to muscarinic receptors. Iloperidone also has an off-label use for treating agitation and psychosis associated with dementia. Iloperidone has been reported as an effective antipsychotic similar to other typical and atypical antipsychotics to reduce the symptoms of schizophrenia. Some of the significant but milder side effects of iloperidone use include dizziness, syncope and hypotension. Iloperidone can cause QTc interval prolongation. Neuroleptic malignant syndrome is a rare and potentially fatal adverse drug reaction that has been reported with antipsychotic drug use. Overall, iloperidone has showed improved safety and tolerability profiles over some other antipsychotics. Iloperidone has been described as a useful psychotropic agent to prevent relapse in stabilized patients and the drug’s efficacy in the treatment of chronic mental illness continues to be studied.

Course Format

Homestudy

Course Syllabus

  • I. Introduction
  • II. Pharmacological Profile
    • 1.        Category
    • 2.        Mechanism of Action
    • 3.        Labeled Use
    • 4.        Off-Label Use
    • 5.        Dosing
    • 6.        Dosing Adjustment: Geriatric Patients
    • 7.        Dosing Adjustment: Hepatic Impairment
    • 8.        Dosing Adjustment: Renal Impairment
    • 9.        Dosing Adjustment: CYP2D6 and CYP3A4 Inhibitors
    • 10.    Discontinuation
    • 11.    Available Forms
    • 12.    Contraindications
    • 13.    US Boxed Warning
    • 14.    Adverse Effect
    • 15.    Warnings and Precautions
    • 16.    Drug Interactions
    • 17.    Pregnancy and Breastfeeding
  • III. Clinical Pearls: Iloperidone
  • IV. Pregnancy and Breastfeeding
  • V. Iloperidone Overdose
  • VI. Case Study: Iloperidone
  • VII. Summary

Author

Dana Bartlett, RN, BSN, MSN, MA, CSPI

Dana Bartlett is a professional nurse and author. His clinical experience includes 16 years of ICU and ER experience and over 27 years as a poison control center information specialist. Dana has published numerous CE and journal articles, written NCLEX material, textbook chapters, and more than 100 online CE articles, and done editing and reviewing for publishers such as Elsevier, Lippincott, and Thieme. He has written widely on the subject of toxicology and was a contributing editor, toxicology section, for Critical Care Nurse journal. He is currently employed at the Connecticut Poison Control Center. He lives in Wappingers Falls, NY.