Course Summary

Expiration Date: 09/30/2028

Drug interactions and adverse drug reactions (ADRs) remain significant causes of preventable harm in clinical practice, especially among patients receiving complex or high-risk pharmacotherapy. Interactions may occur through pharmacokinetic mechanisms, altering absorption, distribution, metabolism, or excretion, or through pharmacodynamic pathways involving additive, synergistic, or antagonistic effects. An in-depth review of drug interaction mechanisms is provided, emphasizing the role of therapeutic drug monitoring (TDM) for medications with narrow therapeutic windows, and outlining clinical strategies for recognizing and preventing toxicity.

Course Format

Homestudy

Course Syllabus

  • Introduction
  • Mechanisms and Classification of Drug Interactions
  • Principles and Application of Therapeutic Drug Monitoring
  • Monitoring Based on Receptor Activity and Pharmacologic Targets
  • Clinical Implementation and Monitoring Strategies
  • Prevention of Adverse Drug Reactions
  • CASE STUDY: HIGH-DOSE VANCOMYCIN, LOW SERUM LEVELS
    • Introduction and Background
    • Case Presentation
  • Summary

Authors

Richard Daniels, PharmD, BCPS

Richard “Cole” Daniels earned his Doctor of Pharmacy(PharmD) from the Skaggs School of Pharmacy at the University of Montana in 2018. Throughout pharmacy school he completed a 3-year internship at Community Medical Center in Missoula, Montana in which he gained valuable experience in an acute care setting. Cole currently serves as a psychiatric clinical staff pharmacist at the Montana State Hospital. He has over 11 years of pharmacy experience having worked in several settings including retail, acute care, and inpatient psychiatric care. Cole has a diverse set of interests. However, acute care medicine, infectious disease, pain management, and asthma/COPD are a primary focus of his at the Montana State Hospital. He obtained board certification as a certified pharmacotherapy specialist in the Spring of 2022.

Elisabeth Gordon, BScPharm, RPh

Elisabeth Gordon earned her BSc(Pharm) from the University of British Columbia in 2004. After graduation, she worked in community retail pharmacies on Vancouver Island, before returning to her rural hometown of Salmon Arm. In 2016 and 2017, Elisabeth trained with Pallium Canada and Victoria Hospice to enhance her knowledge of end-of-life-care and palliative services. She is a volunteer medical supervisor for T1DOutreach, a peer support platform for adults living with type 1 diabetes, and a member of a Canadian peer support group for adults living with Birdshot Uveitis. Elisabeth enjoys working in a small, fast-paced rural pharmacy where she brings compassion and empathy to her everyday practice.