Antidepressants: A Review of Historical Use, Current Understanding, and Future Prospects N575

1 Lesson 2.5 Credit Hours
2.5 Pharmacology Hours
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Course Summary

Expiration Date: 10/20/2028

The pharmacologic treatment of depression necessitates a comprehensive understanding of the historical evolution, current insights, and future trajectories of antidepressant medications. It is crucial to grasp the monoamine hypothesis and various theories regarding the pathogenesis of depression, including hypothalamic-pituitary-adrenal (HPA) axis dysregulation, neuroinflammation, and glutamate. This also encompasses knowledge of the mechanism of action, contraindications, drug interactions, and adverse effects of the different classes of currently available antidepressants. A shift towards newer treatment approaches beyond solely targeting monoamines is exemplified by the rising use of ketamine and esketamine.

Course Format

Homestudy

Course Syllabus

Introduction
Historical Overview
History of the Monoamine Hypothesis
- Reserpine
- Iproniazid and INH
- Chlorpromazine and Phenothiazines
- The Monoamine Hypothesis
Other Theories on the Pathogenesis of Depression
- Hypothalamic-Pituitary-Adrenal (HPA) Axis Dysregulation
- Neuroinflammation
- Glutamate
Categories of Antidepressants
- Selective Serotonin Reuptake Inhibitors
- Serotonin Norepinephrine Reuptake Inhibitors
Tricyclic Antidepressants
Atypical and Newer Generation Antidepressants
- Bupropion
- Mirtazapine
- Nefazodone
- Trazodone
- Vilazodone
- Vortioxetine
Esketamine
Withdrawal Syndrome
Summary

Author

Dana Bartlett, RN, BSN, MSN, MA, CSPI

Dana Bartlett is a professional nurse and author. His clinical experience includes 16 years of ICU and ER experience and over 27 years as a poison control center information specialist. Dana has published numerous CE and journal articles, written NCLEX material, textbook chapters, and more than 100 online CE articles, and done editing and reviewing for publishers such as Elsevier, Lippincott, and Thieme. He has written widely on the subject of toxicology and was a contributing editor, toxicology section, for Critical Care Nurse journal. He is currently employed at the Connecticut Poison Control Center. He lives in Wappingers Falls, NY.