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Author: Dana Bartlett, BSN, MSN, MA, CSPI
(Click author's name for bio)

CE: 2.5 hours Pharmacology: 2.5 hours
Rated 4.8 out of 5.0 based on 557 reviews

Course Summary

Along with other antiseizure drugs, zonisamide is grouped by its principal mode of action, although multiple actions of zonisamide may exist. Zonisamide is considered a broad-spectrum anticovulsant with proven efficacy in randomized, controlled trials as add-on therapy for both focal and generalized seizures in adults and children. There has been clinical experience that indicates that zonisamide is an effective monotherapy for seizures, as well. Zonisamide is generally known to offer improved versatility with less side effects than other antiepileptic drugs, however a greater clinical understanding of zonisamide is needed. Cases of rare and life-threatening reactions to zonisamide, such as Stevens-Johnson syndrome and toxic epidermal necrolysis, have been reported.

Course Format


Course Syllabus

I.              Introduction

II.           Pharmacological Profile

1.         Category

2.         Uses

3.         Mechanism of Action

4.         Available Forms

5.         Dosing

6.         Dosing Adjustment: Geriatric Patients

7.         Dosing Adjustment: Hepatic Impairment

8.         Dosing Adjustment: Renal Impairment

9.         Contraindications

10.     Warnings

11.     Adverse Reactions

12.     Use During Pregnancy and Breastfeeding

13.     Dietary Issues

III.         Clinical Pearls: Zonisamide

IV.          Zonisamide Overdose

V.            Case Study

1.   Discussion

VI.          Summary


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