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Psychotropics and Hyperprolactinemia

Author: Kellie Wilson, PharmD, Susan DePasquale, FPMHNP-BC

CE: 2 hours Pharmacology: 2 hours
Rated 4.7 out of 5.0 based on 2589 reviews

Course Summary

Hyperprolactinemia is a well-known occurrence in patient’s diagnosed with mental disorders, notably schizophrenia and bipolar disorder, who are treated with psychotropic medications. Antipsychotic medications in particular may lead to antipsychotic-induced hyperprolactinemia. When reviewing the clinical effects of hyperprolactinemia with patients, healthcare providers should be discussing common clinical consequences and possible options of therapy. People who are diagnosed with a serious mental illness are at higher risk of developing hyperprolactinemia than healthy people within the general population, and they require routine serum prolactin testing and physical assessment to determine whether complications of treatment have occurred. Hyperprolactinemia may cause clinically significant concerns that require careful consideration, on a case-by-case basis, of the benefits and risks of treating a patient with psychotropic or antipsychotic medications. There are many other causes of hyperprolactinemia that should be considered for differential diagnosis.

Course Format


Course Syllabus

I.    Introduction

II.    Prolactin: Secretion and Function

1. Estrogen and Progesterone
2. Other Factors Regulating Prolactin Secretion
3. Function of Prolactin

III.    Antipsychotic-induced Hyperprolactinemia

IV.    Other Causes of Hyperprolactinemia

V.    Case Study: Aripiprazole and Levels of Hyperprolactinemia

VI.    Case Study: Hyperprolactinemia and Bromocriptine

VII.    Summary


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