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Prochlorperazine: Clinical Utility and Risks for Antiemetic and Psychiatric Treatment

Author: Richard Daniels, PharmD, BCPS
(Click author's name for bio)

CE: 2 hours Pharmacology: 2 hours
Rated 4.7 out of 5.0 based on 1632 reviews

Course Summary

Prochlorperazine is a medication belonging to the class of typical antipsychotics, primarily prescribed to alleviate severe nausea, vomiting (including chemotherapy-induced nausea), and symptoms of anxiety and agitation in certain medical situations. It is also occasionally used to treat acute migraine headaches and, to a limited extent, manage symptoms of psychotic disorders like schizophrenia. Prochlorperazine is within the phenothiazine class of antipsychotic medications and functions by blocking the effects of dopamine in the brain, helping to control the targeted symptoms. It has a well-known affinity for dopamine receptors and muscarinic-cholinergic, histamine H1 and a-adrenoceptors. Prochlorperazine has been described as having slow absorption and a low bioavailability following oral dosing. Adverse reactions to prochlorperazine generally occur with chronic dosing, such as Parkinsonism. Few published studies exist that compare prochlorperazine with other common antiemetic drugs in the treatment of specific disorders and for use in children. Clinicians are recommended to choose a drug based on the clinical scenario and patient preference related to drug administration and safety.

Course Format


Course Syllabus

  1. Introduction
  1. Pharmacological Profile
  1. Uses, Dosing, and Administration
  2. Hepatic and Renal Impairment: Dosing Adjustments
  3. Geriatric Patients: Dosing Adjustment
  1. Treatment for Nausea and Vomiting
  1. Chemotherapy-induced
  2. Pre- and Postoperative
  3. Pregnancy-related
  1. Treatment for Psychiatric Disorders
  1. Warnings and Precautions
  1. Anticholinergic Effects
  2. Cardiopulmonary
  3. Central Nervous System
  4. Gastrointestinal and Hepatic
  5. Hematologic
  6. Neuroleptic Malignant Syndrome
  7. Hyperprolactinemia
  8. Renal
  9. Temperature Regulation
  10. Pregnancy and Breastfeeding
  11. Drug-Drug Interactions
  1. Prochlorperazine Overdose
  1. Case Study: Prochlorperazine
  1. Summary


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