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Author: Dana Bartlett, BSN, MSN, MA, CSPI
(Click author's name for bio)

CE: 2.5 hours Pharmacology: 2.5 hours
Rated 4.7 out of 5.0 based on 1254 reviews

Course Summary

Prazosin (Minipress®) is an a1 adrenoceptor antagonist that blocks excessive responsiveness to norepinephrine stimulation at postsynaptic a1 adrenergic receptor. The maximum dose recommended in the prazosin is 40 mg daily. High-dose prazosin is believed to help alleviate symptoms of post-traumatic stress disorder (PTSD) with comorbid depression and anxiety. Often, clinicians are unsure of how to dose or divide the dose of prazosin to effectively manage symptoms. The titration and proper treatment of prazosin should be based on individual response to the drug and observed side effects. Prazosin should be gradually titrated to avoid the unpleasant side effect of dizziness, and patients need to be educated about the possible risks as well as the benefits or primary symptoms being treated.

Course Format


Course Syllabus

1. Introduction
2. Pharmacology Profile

1. Category
2. Mechanism of Action
3. Unlabeled Use
4. Disease States (common)
5. Available Forms
6. Dosing (Adult)
7. Pediatric Dosing
8. Dosing Adjustment

1. Geriatric Patients
2. Hepatic Impairments
3. Renal Impairment

9. Overdose
10. Contradictions
11. Warnings
12. Precautions
13. Adverse Effects
14. Drug-Drug Interactions
15. Pregnancy and Breastfeeding

1. Overdose

16. Clinical Pearls: Prazosin

3. Case Studies: Prazosin

1. Case Studies: Bipolar 2 Disorder and PTSD
2. Discussion: Bipolar 2 Disorder and PTSD
3. Case Study: PTSD in Adolescents
4. Discussion: PTSD in Adolescents
5. Case Study: Randomized Trial: Post-traumatic Stress Disorder in US Veterans
6. Discussion: Randomized Trial: Post-traumatic Stress Disorder in US Veterans

4. Summary


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