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Author: Dana Bartlett, BSN, MSN, MA, CSPI
(Click author's name for bio)

CE: 2.5 hours Pharmacology: 2.5 hours
Rated 4.7 out of 5.0 based on 828 reviews

Course Summary

Phenytoin indications, clinical use and the potential for toxicity have been well reviewed in the literature. Phenytoin is often used in combination with other types of anticonvulsant medication and classes of medications, such as benzodiazepines, for varied clinical conditions. The drug is commonly regarded as an antiepileptic agent however it has been used for other conditions as well as a prophylactic agent in neurosurgical patients to avoid an epileptic condition. The research on phenytoin indication, use and potential adverse outcomes focuses on the necessary balance of clinical observation and indication, laboratory data trending serum drug levels, and pharmacological guidelines guiding drug combinations and cross titrations/tapers in certain epileptic conditions to achieve medical stability.

Course Format


Course Syllabus

I.              Introduction

II.           Pharmacological Profile

1.         Category

2.         Uses

3.         Mechanisms of Action

4.         Available Forms

5.         Dosing

6.         Dosing Adjustment: Geriatric Patient

7.         Dosing Adjustment: Hepatic Impairment

8.         Dosing Adjustment: Renal Impairment

9.         Dosing Adjustment: Obesity

10.     US Boxed Warning

11.     Contraindications

12.     Warnings

13.     Adverse Reactions

14.     Use During Pregnancy and Breastfeeding

15.     Diet

III.         Phenytoin Blood Level and Other Laboratory Tests

IV.          Seizure Types

1.   Generalized Tonic-Clonic Seizures

2.   Complex Partial (Psychomotor and Temporal Lobe) Seizures

3.   Status Epilepticus

4.   Neurosurgery and Seizures

V.            Clinical Pearls: Phenytoin

VI.          Phenytoin Overdose

1.   Patient Groups and Comorbidities

2.   Treatment Compliance, Drug Levels and Complications

VII.       Case Study

1.   Discussion

VIII.     Summary


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