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Author: Dana Bartlett, BSN, MSN, MA, CSPI
(Click author's name for bio)

CE: 2.5 hours Pharmacology: 2.5 hours
Rated 4.8 out of 5.0 based on 980 reviews

Course Summary

Perphenazine is a typical antipsychotic and a centrally acting dopamine D2 receptor antagonist with a labeled use to treat schizophrenia. It is also used to help allay symptoms of nausea and vomiting. Off-label, perphenazine is used to control agitation or psychosis caused by dementia, however clinicians are warned of the increased risk of death when using typical antipsychotics in elderly individuals. Use of perphenazine as with all first generation antipsychotics has been less preferred compared to second generation atypical antipsychotics that are associated with improved drug safety and tolerability. However, clinicians should also consider the longitudinal data associated with a clinical and therapeutic course of care in individual patients. Alongside a concern for drug safety and tolerance, antipsychotic drug treatment should also be tailored to individual patient symptoms and outcomes.

Course Format


Course Syllabus

I.              Introduction

II.           Pharmacological Profile

1.         Drug Category

2.         Mechanism of Action

3.         Labeled Uses

4.         Off-Label Uses

5.         Dosing

6.         Available Forms

7.         Dosing Adjustment: Geriatric Patients

8.         Dosing Adjustment: Hepatic Impairment

9.         Dosing Adjustment: Renal Impairment

10.     US Boxed Warning

11.     Contraindications

12.     Adverse Effects

13.     Warnings and Precautions

14.     Pregnancy and Breastfeeding

15.     Drug-drug Interactions

III.        Clinical Pearls: Perphenazine

IV.         Perphenazine Overdose

V.            Case Study: Perphenazine

1.   Discussion

VI.         Summary


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