I. Introduction
II. DSM-5 Criteria: Comorbid Bipolar and Substance Use Disorder
1. Neurobiological Pathways
2. Genetics
3. Cannabis Use and Psychosis
4. Emotions and Energy
III. Mood Disorder and Self-Medicating
1. Co-occurring Substance Use and Mood Disorder
2. Cannabis Use and Bipolar Disorder
3. Alcohol Use and Bipolar Disorder
4. Stimulant Use and Bipolar Disorder
5. Self-medicating to “Help Treatment Along”
IV. Substance Use as a Mood Trigger
1. Medication-induced Mania
2. Cannabis and Mania
3. Alcohol and Other Substance-induced Mania
V. Identification of a Drug-induced Mood Disorder
VI. Case Study: Cannabis-induced Bipolar Disorder Episode
VII. Summary