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Iloperidone

Author: Dana Bartlett, BSN, MSN, MA, CSPI
(Click author's name for bio)

CE: 2.5 hours Pharmacology: 2.5 hours
Rated 4.8 out of 5.0 based on 80 reviews

Course Summary

Iloperidone (Fanapt®) is a second-generation atypical antipsychotic that is used for the treatment of schizophrenia. The drug acts at dopamine and serotonin receptor sites, has a low affinity for histamine receptors, and it does not bind to muscarinic receptors. Iloperidone also has an off-label use for treating agitation and psychosis associated with dementia. Iloperidone has been reported as an effective antipsychotic similar to other typical and atypical antipsychotics to reduce the symptoms of schizophrenia. Some of the significant but milder side effects of iloperidone use include dizziness, syncope and hypotension. Iloperidone can cause QTc interval prolongation. Neuroleptic malignant syndrome is a rare and potentially fatal adverse drug reaction that has been reported with antipsychotic drug use. Overall, iloperidone has showed improved safety and tolerability profiles over some other antipsychotics. Iloperidone has been described as a useful psychotropic agent to prevent relapse in stabilized patients and the drug’s efficacy in the treatment of chronic mental illness continues to be studied.

Course Format

Homestudy

Course Syllabus

I. Introduction
II. Pharmacological Profile

1.        Category
2.        Mechanism of Action
3.        Labeled Use
4.        Off-Label Use
5.        Dosing
6.        Dosing Adjustment: Geriatric Patients
7.        Dosing Adjustment: Hepatic Impairment
8.        Dosing Adjustment: Renal Impairment
9.        Dosing Adjustment: CYP2D6 and CYP3A4 Inhibitors
10.    Discontinuation
11.    Available Forms
12.    Contraindications
13.    US Boxed Warning
14.    Adverse Effect
15.    Warnings and Precautions
16.    Drug Interactions
17.    Pregnancy and Breastfeeding

III. Clinical Pearls: Iloperidone
IV. Pregnancy and Breastfeeding
V. Iloperidone Overdose
VI. Case Study: Iloperidone
VII. Summary

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