I. Introduction
II. GERD Epidemiology and Pathophysiology
1. GERD and FGID Disease Overlap
2. Prevalence Rates
III. Lower Esophageal Sphincter and GERD
1. GERD Defined
2. Dyspepsia and Other Common GERD Symptoms
IV. Risk Factors of GERD
1. Postprandial Gastric Acid
2. Transient Lower Esophageal Sphincter Relaxation
V. Diagnosis of GERD
1. Ambulatory Acid pH Probe Test
2. Endoscopy
3. Esophageal Manometry (Motility) Testing
VI. Complications of GERD
1. Esophageal Stricture
2. Esophageal Ulcer
3. Throat and Lung Symptoms
4. Barrett’s Esophagus
5. Esophageal Cancer
VII. Treatment of GERD
1. Erosive versus Non-erosive Subtypes
2. PPI and Lifestyle Treatment: A Standard Approach
3. Medication: Non-prescriptive and Prescriptive Strength
4. Nissen Fundoplication
5. Linx Device
VIII. Summary