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Fluphenazine: Treatment Benefits and Risks in Adult and Geriatric Populations

Author: Richard "Cole" Daniels, PharmD, BCPS

CE: 2 hours Pharmacology: 2 hours
Rated 4.7 out of 5.0 based on 940 reviews

Course Summary

Fluphenazine is an antipsychotic that is used for the treatment of patients who have a psychotic disorder. It is used off-label to treat chorea associated with Huntington’s disease, chronic tic disorders, psychosis, and agitation associated with dementia. Fluphenazine is a piperazine phenothiazine. The phenothiazines are a class of medications that are used as antiemetics and to treat psychiatric disorders. Fluphenazine’s mechanism of action is not completely understood, but its antipsychotic effect is likely mediated through selective blockade of dopamine receptors in the brain. Fluphenazine may also affect peripheral alpha-adrenergic receptors, histamine receptors, and muscarinic receptors, but fluphenazine’s ability to block these receptors is considered limited.

Course Format


Course Syllabus

  1. Introduction
  1. Pharmacological Profile
  1. Labeled and Off-label Use
  2. Dosing and Available Forms
  3. US Boxed Warning, Contraindications, and Adverse Effects
  1. Warnings and Precautions
  1. Anticholinergic Effects
  2. Cardiovascular
  3. Central Nervous System
  4. Neuroleptic Malignant Syndrome
  5. Gastrointestinal
  6. Hematologic
  7. Ophthalmic
  8. Prolactin Levels
  9. Seizure Disorder
  10. Venous Thromboembolism
  11. Pregnancy and Breastfeeding
  12. Drug Interactions, Withdrawal/Discontinuation
  13. Overdose
  1. Case Study: Fluphenazine
  1. Summary


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