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Digoxin - Pharmacology: Therapeutic And Toxic Drug Effects

Author: Dana Bartlett, BSN, MSN, MA, CSPI
(Click author's name for bio)

CE: 2.5 hours Pharmacology: 2.5 hours
Rated 4.8 out of 5.0 based on 2639 reviews

Course Summary

Digoxin has been used to maintain a stable heart rate for many years. It has been recommended as a first-line drug for individuals diagnosed with atrial fibrillation and congestive heart failure. The action of digoxin is mediated through its effects on the heart, on other parts of the cardiovascular system, and on the renin-angiotensin system. While the use of digoxin has declined significantly, and other drugs have replaced its use in the clinical setting of severe congestive heart failure and cardiomegaly, it still has therapeutic value. The pharmacological profile of digoxin as well as its toxic effects are discussed.

Course Format


Course Syllabus

I.       Introduction

II.                  History Of Digoxin

III.                Cardiac Glycosides

IV.                Digoxin Pharmacotherapy

1.      Cardiac Effect

2.      Cardiovascular System

3.      Renin-Angiotensin System

V.                  Pharmacokinetics Of Digoxin

1.      Drug Absorption

2.      Drug Distribution

3.      Drug Metabolism

4.      Drug Excretion

VI.                Clinical Indications For Digoxin

1.      Atrial Fibrillation

2.      Heart Failure

VII.              Digoxin Therapy

1.      Pre-treatment Assessment

2.      Initial Therapy

3.      Drug-drug Interactions

4.      Patient Monitoring

VIII.            Digoxin Toxicity

1.      Causes

2.      Clinical Presentation

3.      Digoxin Poisoning: Serum Levels

IX.                Treatment For Digoxin Poisoning

X.                  Summary


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