I. Introduction
II. Pharmacological Profile
1. Mechanism of Action
2. Dosing and Dosing Adjustments
3. Adverse Reactions
4. Adverse Effects: Epidural
5. US Box Warning, Contraindications, and Warnings
6. Disease-Related Concerns
7. Medication-Related Issues
8. Administration Issues
9. Pregnancy and Breastfeeding
10. Dietary Recommendations
11. Treatment Resistant Hypertension
12. Pressor Response
III. Clonidine Withdrawal Syndrome
IV. Clonidine Overdose and Accidental Exposure
Naloxone
V. Case Study: Clonidine Overdose
1. Accidental Overdose in a Toddler
2. Adult with Clonidine Overdose
VI. Summary