I. Introduction
II. The DSM-5 and Substance Use Disorders
1. DSM-5 Guidelines for Substance-Related Disorders
2. Tolerance
3. Withdrawal
III. Multiple Substance Use
IV. Progression of a Substance Use Disorder
V. Common Risk Factors for Substance Use
1. Homelessness
2. Personality Disorders
3. Comorbid Psychiatric Disorders
4. Dual Pathology
5. Comorbid Mental Illness and Other Behavioral Addictions
VI. Screening for Substance Use
1. Physiological Category
2. Psychological Category
3. Behavioral Category
4. Biological Screens
5. Dimensions of Substance Use
VII. Screening Instruments for Substance Use
1. CAGE and CAGE-AID
2. Alcohol Use Disorders Identification Test
3. Michigan Alcoholism Screening Test
4. Short Michigan Alcoholism Screening Test
5. Drug Abuse Screening Test
VIII. Case Study: Substance Use Disorder in a Young Male
IX. Summary