I. Introduction
II. Disease Prevalence
III. Risk Factors of Clostridium Difficile
1. Antibiotic or Other Medication Use
2. Nosocomial Infection
IV. Diagnosis of Clostridium Difficile
1. Polymerase Chain Reaction
2. Cell Cytotoxicity Assay
3. Sigmoidoscopy/Colonoscopy
4. Imaging Tests
5. Complications of CDI
V. Symptoms of Clostridium Difficile
1. Mild to Moderate Infection
2. Severe Infection
VI. Treatment of Clostridium Difficile
1. Antibiotic Therapy
2. Surgery
VII. Recurrent Clostridium Difficile Infection
1. Medical Treatment
VIII. Prevention of CDI Transmission
1. Surveillance
2. Early Detection and Contact Precaution
3. Environmental Cleaning
4. Chlorhexidine Bathing
5. Antibiotic Stewardship
6. Gastric Acid Suppression
IX. Summary