I. Introduction
II. Incidence of Acetaminophen Overdose
III. Acetaminophen: Pharmacology
1. Labeled Uses and Mechanism of Action
2. Pharmacokinetics
3. Dosing
4. Available Forms
5. Contraindications, Cautions and Side Effects
6. Drug-Drug Interactions
IV. Acetaminophen: Toxic Dose
V. Therapeutic Dose and Toxicity
VI. Repeated Supratherapeutic Ingestion and Overdose
VII. Clinical Presentation of Acetaminophen Poisoning
1. Phase I
2. Phase II
3. Phase III
4. Phase IV
5. Renal and Other Organ Injury
VIII. Risk Factors of Acetaminophen Poisoning
1. Alcohol and Acetaminophen Poisoning
2. Age
3. Genetics
4. Chronic Liver Disease
5. Poor Nutritional Status
6. Cigarette Smoking
7. Medications
8. Intrahepatic Glutathione Levels
9. Acute Viral Illness
IX. Diagnosis of Acute Acetaminophen Overdose
1. Serum Acetaminophen Level
2. Laboratory Tests
3. Rumack-Matthew Nomogram
4. Repeated Supratherapeutic Ingestion, Delayed Presentation, and Unknown Time of Ingestion
X. Treatment of Acetaminophen Overdose
1. Activated Charcoal
2. N-Acetylcysteine (NAC)
3. Fomepizole
4. Acetaminophen Overdose: Ambiguous and/or Missing Data
XI. Special Cases of Acetaminophen Poisoning: Pregnancy and Liver Failure
1. Pregnancy and Acetaminophen Overdose
2. Acute Liver Failure
XII. Case Study: Acetaminophen Poisoning
Discussion
XIII. Summary