I. Introduction
II. Pharmacology of Cocaine
1. Neurotransmitter Blockade and Release
2. Ion Channel Blockade
3. Excitatory Neurotransmitter Release
III. Acute Cocaine Intoxication
1. Cardiovascular
2. Central Nervous System
3. Pulmonary
4. Other Organ System Toxicity
IV. Cocaine Use Disorder Diagnosis
1. Incidence of Cocaine Use
2. Screening for Cocaine Use
3. DSM-5 Criteria
V. Treatment of Cocaine Use Disorder
1. Pharmacotherapy
2. Amphetamine
3. Methylphenidate
4. Bupropion
VI. Case Study: Charlie’s Story
VII. Summary