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Cocaine Use Disorder

Author: Dana Bartlett, BSN, MSN, MA, CSPI
(Click author's name for bio)

CE: 2.5 hours Pharmacology: 2.5 hours
Rated 4.7 out of 5.0 based on 4164 reviews

Course Summary

Cocaine addiction is a serious public health problem. Millions of Americans regularly use cocaine, and some develop a substance use disorder. Cocaine is generally not ingested, but toxicity and death from gastrointestinal absorption has been known to occur. Medications that have been used as substitution therapy for the treatment of a cocaine use disorder include amphetamine, bupropion, methylphenidate, and modafinil. While pharmacological interventions can be effective, a recent review of pharmacological therapy for cocaine use indicates that psycho-social efforts are more consistent over medication as a treatment option.

Course Format


Course Syllabus

I.              Introduction
II.           Pharmacology of Cocaine
1.   Neurotransmitter Blockade and Release
2.   Ion Channel Blockade
3.   Excitatory Neurotransmitter Release
III.         Acute Cocaine Intoxication
1.   Cardiovascular
2.   Central Nervous System
3.   Pulmonary
4.   Other Organ System Toxicity
IV.          Cocaine Use Disorder Diagnosis
1.   Incidence of Cocaine Use
2.   Screening for Cocaine Use
3.   DSM-5 Criteria
V.            Treatment of Cocaine Use Disorder
1.   Pharmacotherapy
2.   Amphetamine
3.   Methylphenidate
4.   Bupropion
VI.          Case Study: Charlie’s Story
VII.       Summary


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