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Alpha1-adrenergic Blocking Medication

Author: Noah Carpenter, MD and Kellie Wilson, PharmD

CE: 2 hours Pharmacology: 2 hours
Rated 4.6 out of 5.0 based on 5871 reviews

Course Summary

Antihypertensive medications are used to treat heart disease and stroke, as well as comorbid conditions of the urinary and peripheral vascular systems. The use of an antihypertensive medication lowers blood pressure and improves health outcomes of patients by slowing disease outcomes caused by cardiovascular morbidity. Amongst the classes of drugs used to treat hypertension and cardiovascular disease, alpha1-adrenergic-blocking drugs are often used as second-line agents or in combination with other antihypertensive agents to manage symptoms. The effectiveness of alpha1-adrenergic-blocking medication in certain medical conditions and populations may also include men with benign prostatic hypertrophy. In older individuals, clinicians need to educate patients about the possibility of an initial adverse outcome of symptomatic hypotension and the risk of a drug-drug interaction leading to a severe physical response and injury.

Course Format


Course Syllabus

I.         Introduction

II.         Alpha1-adrenergic Blocking Medication

1. Mechanism of Action
2. Usage, Available Forms and Dosin
3. Geriatrics, Hepatic and Renal Impairment: Dosing Adjustments
4. Contraindications and Warnings
5. Adverse Reactions
6. Pregnancy and Breastfeeding

III.         Labeled Uses and Treatment of Hypertension

      Overdose of Doxazosin, Prazosin, and Terazosin

IV.         Case Study: Doxazosin-induced Hypotension


V.         Summary


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