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Author: Dana Bartlett, BSN, MSN, MA, CSPI
(Click author's name for bio)

CE: 2.5 hours Pharmacology: 2.5 hours
Rated 4.7 out of 5.0 based on 421 reviews

Course Summary

Trifluoperazine is a phenothiazine and well-known typical antipsychotic drug used to treat patients diagnosed with generalized non-psychotic anxiety and schizophrenia and the prevention of relapse. It has been used successfully for many years as an adjunct for manic, impulsive, and aggressive behaviors, such as with autistic individuals. There are drug side effects that occur with typical antipsychotic drugs, especially those affecting the extrapyramidal motor system. The extrapyramidal reactions in people taking phenothiazines is believed to be due to blockade of central dopaminergic receptors affecting motor function, and generally occur at higher doses. The extrapyramidal reactions caused by phenothiazines have been predominantly described as dystonic reactions, motor restlessness and parkinsonian type symptoms. While the drug’s common use has declined in the United States, trifluoperazine is still a preferred agent in some jurisdictions because of its low cost and efficacy when used in combination with other psychotropic medication.

Course Format


Course Syllabus

I.         Introduction
II.         Pharmacological Profile
1.   Category
2.   Mechanism of Action
3.   Labeled Uses
4.   Unlabeled Use
5.   Dosing
6.   Dosing Adjustment: Geriatric Patients
7.   Dosing Adjustment: Hepatic Impairment
8.   Dosing Adjustment: Renal Impairment
9.   US Boxed Warning
10.                 Contraindications
11.                 Adverse Effects
12.                 Warnings and Precautions
13.                 Pregnancy and Breastfeeding
14.                 Drug-Drug Interactions
III.         Clinical Pearls: Trifluoperazine
IV.         Trifluoperazine Overdose
V.         Case Study: Trifluoperazine
1.   Case Study 1: Antipsychotic Drug Use and Hypokalemia
2.   Case Study 1: Discussion
3.   Case Study 2: Depressive Episode
4.   Case Study 2: Discussion
VI.         Summary


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