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Thiothixene Treatment for Schizophrenia: Anticholinergic and Dopamine Blocking Action

Author: Richard "Cole" Daniels, PharmD, BCPS

CE: 2.5 hours Pharmacology: 2.5 hours
Rated 4.8 out of 5.0 based on 879 reviews

Course Summary

Thiothixene is an antipsychotic medication that belongs to the class of thioxanthenes. It is primarily used to treat schizophrenia and other psychotic disorders, effectively alleviating symptoms such as hallucinations, delusions, and disorganized thinking. Thiothixene blocks certain neurotransmitter receptors, particularly dopamine receptors, in the brain, thereby reducing the excess dopamine activity associated with psychotic conditions. Though effective, thiothixene may cause side effects such as drowsiness, dizziness, and movement disorders. The use of thiothixene has significantly declined in recent decades with the advent of the newer atypical antipsychotics, however, it continues to be manufactured and used in many countries worldwide.

Course Format


Course Syllabus

  1. Introduction

  2. Pharmacological Profile and Uses

    1. Dosing and Available Forms

    2. Dosing Adjustment: Geriatric Patients

    3. Dosing Adjustment: Hepatic and Renal Impairment

  3. Thiothixene Contraindications, Adverse Effects, and Warnings

    1. Potential Adverse Effects

    2. Pregnancy and Breastfeeding

    3. Drug-Drug Interactions and Withdrawal/Discontinuation

  4. Thiothixene Overdose

  5. Case Study: Thiothixene Wrongful Administration

  6. Summary


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