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Thioridazine: A Typical Antipsychotic Treatment of Schizophrenia

Author: Richard Daniels, PharmD, BCPS
(Click author's name for bio)

CE: 2 hours Pharmacology: 2 hours
Rated 4.8 out of 5.0 based on 966 reviews

Course Summary

Thioridazine is a first-generation, typical antipsychotic used to treat schizophrenia. It acts as a centrally acting dopamine receptor antagonist that also serves as an antagonist at histamine, noradrenaline, and serotonin receptors. In recent years, thioridazine has been replaced by many of the atypical antipsychotics that are known to have fewer extrapyramidal side effects. Warnings exist with the use of thioridazine relative to cardiac complications and an increased risk of sudden death, and there are age-related complications, such as hypertension and increased fall risk. The common side effects, risks, and benefits of thioridazine are discussed.

Course Format


Course Syllabus

  1. Introduction
  1. Pharmacological Profile, Dosing, Uses, and Warnings
  1. Recommended Dosing
  2. Dosage Strengths and Adjustments
  1. Drug Warnings, Contraindications, and Adverse Effects
  1. Warnings and Precautions of Thioridazine Use
  1. Anticholinergic Effects
  2. Cardiovascular
  3. Central Nervous System: Extrapyramidal Symptoms
  4. Falls
  5. Gastrointestinal
  6. Hematologic
  7. Neuroleptic Malignant Syndrome
  8. Ophthalmic
  9. Prolactin Levels
  10. Seizures
  11. Venous Thromboembolism
  12. Withdrawal/Discontinuation
  13. Drug-Drug Interactions
  14. Pregnancy and Breastfeeding
  1. Treatment Uses of Thioridazine
  1. Thioridazine Overdose
  1. Case Study: Thioridazine
  1. Summary


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