I. Introduction
II. Pharmacological Profile
III. Epidemiology
IV. Clinical Effects of Synthetic Cannabis
1. Cardiovascular
2. Central Nervous System
3. Pulmonary
4. Hepatic/Renal
5. Rhabdomyolysis
6. Gastrointestinal
V. Drug Use, Withdrawal and Long-Term Effects
VI. Treatment
VII. Medical Use of Synthetic Cannabis
1. Cancer Cell Viability
2. Obstructive Sleep Apnea
3. Post-traumatic Stress Disorder and Insomnia
VIII. Cannabis Substance Use Disorder
1. Synthetic Cannabis Use and Aggression
IX. Case Study: Synthetic Cannabis and Alcohol Combined Use
X. Case Study: Myocardial Infarction with Synthetic Cannabis Use
XI. Summary