I. Introduction
II. Pharmacological Profile
1. Category
2. Labeled Uses
3. Mechanism of Action
4. Available Forms
5. Dosing
6. Dosing Adjustments
a) Hepatic Impairment
b) Renal Impairment
c) Geriatric Patients
7. Pediatric Patients
8. US Boxed Warning
9. Use During Pregnancy
10. Use During Breastfeeding
11. Contraindications
12. Warnings
13. Adverse Effects
14. Drug Interactions
15. Dietary Considerations
III. Clinical Pearls: Sacubitril/Valsartan
1. Dosing Adjustments
2. Labeled Warnings, Contraindications and Uses
3. Drug Interactions
IV. Case Study: Sacubitril/Valsartan
V. Summary