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Author: Dana Bartlett, RN, BSN, MSN, MA, CSPI and Kellie Wilson, PharmD

CE: 2.5 hours Pharmacology: 2.5 hours
Rated 4.8 out of 5.0 based on 318 reviews

Course Summary

Sacubitril/valsartan is a combination angiotensin II receptor blocker and neprilysin inhibitor, referred to as an angiotensin receptor-neprilysin inhibitor used to treat patients who have heart failure with reduced ejection fraction. The drug is effective for patients who have chronic heart failure with reduced ejection fraction. This drug is usually given with other drugs and is used in place of an angiotensin converting enzyme inhibitor or an angiotensin II receptor blocker.

Course Format


Course Syllabus

I.       Introduction
II.      Pharmacological Profile
1.   Category
2.   Labeled Uses
3.   Mechanism of Action
4.   Available Forms
5.   Dosing
6.   Dosing Adjustments
a)   Hepatic Impairment
b)   Renal Impairment
c)   Geriatric Patients
7.   Pediatric Patients
8.   US Boxed Warning
9.   Use During Pregnancy
10.    Use During Breastfeeding
11.    Contraindications
12.    Warnings
13.    Adverse Effects
14.    Drug Interactions
15.    Dietary Considerations
III.     Clinical Pearls: Sacubitril/Valsartan
1.   Dosing Adjustments
2.   Labeled Warnings, Contraindications and Uses
3.   Drug Interactions
IV.     Case Study: Sacubitril/Valsartan
V.      Summary


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