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Author: Dana Bartlett, BSN, MSN, MA, CSPI
(Click author's name for bio)

CE: 2.5 hours Pharmacology: 2.5 hours
Rated 4.7 out of 5.0 based on 910 reviews

Course Summary

Prochlorperazine is a phenothiazine with antiemetic effect and psychoactive properties. It has been widely used for many years in the prevention and relief of nausea, vomiting, vestibular and psychiatric disorders. The drug has  well-known affinity for dopamine receptors, and muscarinic-cholinergic, histamine H1 and a-adrenoceptors. Prochlorperazine has been described as having slow absorption and a low bioavailability following oral dosing. Some researchers have evaluated the pharmacokinetics and pharmacodynamics of prochlorperazine after intravenous and oral dosing to determine the difference between the two dosing regimens. Adverse reactions to prochlorperazine generally occur with chronic dosing, such as Parkinsonism. Few published studies exist that compare prochlorperazine with other common antiemetic drugs in the treatment of specific disorders. Clinicians are recommended to choose a drug based upon the clinical scenario and patient preference related to drug administration and safety.

Course Format


Course Syllabus

I. Introduction
II. Pharmacologic Profile
1.   Category
2.   Mechanism of Action
3.   Labeled Use
4.   Unlabeled Use
5.   Dosing
6.   Administration
7.   Available Forms
8.   Dosing Adjustment
a.   Geriatric Patients
b.   Hepatic Impairment
c.    Renal Impairment
9.   US Boxed Warning
10.                 Contraindications
11.                 Adverse Effects
12.                 Warnings and Precautions
13.                 Pregnancy and Breastfeeding
14.                 Dietary Considerations
15.                 Laboratory Test Considerations
16.                 Drug-Drug Interactions
III. Clinical Pearls: Prochlorperazine
IV. Prochlorperazine Overdose
V. Case Study: Prochlorperazine
1.   Discussion
VI. Summary


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