I. Introduction
II. Pharmacological Profile
1. Category
2. Labeled Uses
3. Mechanism of Action
4. Available Forms
5. US Boxed Warning
6. Contraindications
7. Drug Warnings
8. Disease-related Concerns
9. Adverse Effects
10. Dosing Adjustment: Hepatic Impairment
11. Dosing Adjustment: Renal Impairment
12. Dosing Adjustment: Heart Failure, Post-MI
13. Dosing Adjustment: Elderly/Geriatric Individuals
14. Use During Pregnancy
15. Use During Breastfeeding
16. Dietary Concerns
III. Prescribing Pearls and Practical Information
1. Hypertension
2. Edema
3. Liver Edema and Cirrhosis
4. Nephrotic Syndrome and Edema
5. Secondary Hyperaldosteronism and Edema
6. Steroid-induced Edema and Idiopathic Edema
7. Heart Failure
8. Post-MI Heart Failure
9. Aldosterone and Myocardial/Vascular Fibrosis
10. Tumorigen Potential of Spironolactone
11. Specific Drug Use Considerations and Recommendations
IV. Summary