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Potassium-Sparing Diuretics

Author: Dana Bartlett, BSN, MSN, MA, CSPI
(Click author's name for bio)

CE: 2.5 hours Pharmacology: 2.5 hours
Rated 4.7 out of 5.0 based on 2573 reviews

Course Summary

Potassium-sparing diuretics prevent resorption of sodium and subsequent loss of potassium at the level of the distal part of the nephron. They are considered a mild diuretic and are used for the treatment of hypertension, edema associated with cirrhosis of the liver, nephrotic syndrome, heart failure, and post-myocardial infarction heart failure. Four potassium-sparing diuretic medication are currently available in the United States - amiloride, eplerenone, spironolactone, and triamterene. The pharmacological profile of the potassium-sparing diuretics, their labeled uses, adverse effects, contraindications, and warnings, as well as patient monitoring during therapy with a potassium-sparing diuretic and patient education issues, are discussed.

Course Format


Course Syllabus

I.              Introduction
II.           Pharmacological Profile
1.   Category
2.   Labeled Uses
3.   Mechanism of Action
4.   Available Forms
5.   US Boxed Warning
6.   Contraindications
7.   Drug Warnings
8.   Disease-related Concerns
9.   Adverse Effects
10.        Dosing Adjustment: Hepatic Impairment
11.        Dosing Adjustment: Renal Impairment
12.        Dosing Adjustment: Heart Failure, Post-MI
13.        Dosing Adjustment: Elderly/Geriatric Individuals
14.        Use During Pregnancy
15.        Use During Breastfeeding
16.        Dietary Concerns
III.        Prescribing Pearls and Practical Information
1.   Hypertension
2.   Edema
3.   Liver Edema and Cirrhosis
4.   Nephrotic Syndrome and Edema
5.   Secondary Hyperaldosteronism and Edema
6.   Steroid-induced Edema and Idiopathic Edema
7.   Heart Failure
8.   Post-MI Heart Failure
9.   Aldosterone and Myocardial/Vascular Fibrosis
10.        Tumorigen Potential of Spironolactone
11.        Specific Drug Use Considerations and Recommendations
IV.         Summary


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