I. Introduction
II. Prescription and Illicit Opiates
III. Substance Use and Withdrawal
1. Physical Symptoms
2. Psychological Symptoms
IV. Treatment Programs for Opioid Withdrawal Symptoms
1. Outpatient Treatment
2. Inpatient Treatment
V. Potential Complications and Treatment Barriers
1. Pregnancy
2. Failure to Transition from Detoxification to Long-Term Treatment
3. Suicide Risk
VI. Pharmacologic Detoxification and Medication-assisted Treatment
1. Detoxification
2. Medication-assisted Treatment (MAT)
3. Treatment Options for Withdrawal and Substance Use Disorder
4. Cognitive Behavioral Therapy and Relapse Prevention
VII. Case Study 1: Opioid Use Disorder and Buprenorphine Treatment
VIII. Case Study 2: Case of Buprenorphine/Naloxone Rapid Taper
IX. Summary