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Loxapine: Oral and Inhalant Treatment for Mood Disorders and Psychosis

Author: Richard "Cole" Daniels, PharmD, BCPS
(Click author's name for bio)

CE: 2 hours Pharmacology: 2 hours
Rated 4.7 out of 5.0 based on 593 reviews

Course Summary

Loxapine is an antipsychotic that is used for the treatment of patients who have schizophrenia. It is known as a typical antipsychotic with a high-potency effect that is often used in lower doses and titrated to effect. Loxapine has low activity at histamine and muscarinic receptors so anticholinergic effects and sedation are less likely to occur, as compared to antipsychotics with a low-potency effect. Loxapine is not only effective for the treatment of symptoms of schizophrenia but also in cases of bipolar disorder, and for major depressive disorder. Clinicians should aim for a therapeutic dose when prescribing loxapine through routine follow-ups and drug monitoring.

Course Format


Course Syllabus

  1. Introduction
  1. Pharmacological Profile
  1. Labeled Uses, Dosing, and Forms
  2. Dosing Adjustments: Geriatric, Hepatic, Renal
  3. US Boxed Warning, Contraindications, and Adverse Events
  1. Common Precautions
  1. Anticholinergic Effects
  2. Orthostatic Hypotension
  3. Cardiac and Sudden Death
  4. Central Nervous System
  5. Falls
  6. Gastrointestinal
  7. Hematologic
  8. Thermoregulation
  9. Neuroleptic Malignant Syndrome
  10. Ophthalmic
  11. Prolactin Levels
  12. Seizure Disorder
  13. Pulmonary
  14. Venous Thromboembolism
  15. Withdrawal/Discontinuation
  16. Pregnancy and Breastfeeding
  17. Drug-Drug Interactions and Overdose
  1. Case Study: Loxapine
  1. Summary


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