Course Summary

Fluphenazine is an antipsychotic that is used for the treatment of patients who have a psychotic disorder. It is used off-label to treat chorea associated with Huntington’s disease, chronic tic disorders, and psychosis and agitation associated with dementia. Fluphenazine is a piperazine phenothiazine. The phenothiazines are a class of medications that are used as antiemetics and to treat psychiatric disorders. Fluphenazine’s mechanism of action is not completely understood but its antipsychotic effect is likely mediated through selective blockade of dopamine receptors in the brain. Fluphenazine may also affect peripheral alpha-adrenergic receptors, histamine receptors, and muscarinic receptors but fluphenazine’s ability to block these receptors is considered limited.

Course Format

Homestudy

Course Syllabus

• I. Introduction
• II. Pharmacological Profile
  • Category
  • Mechanism of Action
  • Labeled Use
  • Off-Label Uses
  • Dosing
  • Available Forms
  • US Boxed Warning
  • Contraindications
  • Dosing Adjustment
    • a. Geriatric Patient
    • b. Hepatic Impairment
    • c. Renal Impairment
  • Adverse Effects
  • Warning and Precautions
  • Pregnancy and Breastfeeding
  • Drug Interactions
• III. Clinical Pearls: Fluphenazine
• IV. Fluphenazine Overdose
  • Case Study: Fluphenazine
  • Discussion
• V. Summary