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Author: Dana Bartlett, BSN, MSN, MA, CSPI
(Click author's name for bio)

CE: 2.5 hours Pharmacology: 2.5 hours
Rated 4.7 out of 5.0 based on 572 reviews

Course Summary

Fluphenazine is an antipsychotic that is used for the treatment of patients who have a psychotic disorder. It is used off-label to treat chorea associated with Huntington’s disease, chronic tic disorders, and psychosis and agitation associated with dementia. Fluphenazine is a piperazine phenothiazine. The phenothiazines are a class of medications that are used as antiemetics and to treat psychiatric disorders. Fluphenazine’s mechanism of action is not completely understood but its antipsychotic effect is likely mediated through selective blockade of dopamine receptors in the brain. Fluphenazine may also affect peripheral alpha-adrenergic receptors, histamine receptors, and muscarinic receptors but fluphenazine’s ability to block these receptors is considered limited.

Course Format


Course Syllabus

I.              Introduction

II.           Pharmacological Profile

1.        Category

2.        Mechanism of Action

3.        Labeled Use

4.        Off-Label Uses

5.        Dosing

6.        Available Forms

7.        US Boxed Warning

8.        Contraindications

9.        Dosing Adjustment

a.   Geriatric Patients

b.   Hepatic Impairment

c.    Renal Impairment

10.    Adverse Effects

11.    Warning and Precautions

12.    Pregnancy and Breastfeeding

13.    Drug Interactions

III.        Clinical Pearls: Fluphenazine

IV.         Fluphenazine Overdose

1.        Case Study: Fluphenazine

2.        Discussion

V.            Summary


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