I. Introduction
II. The Opioid Crisis and Fentanyl Use
III. Key Points of Fentanyl Overdose
1. Detection of Fentanyl
2. History of Use
3. Pattern of Use
4. Pediatric Exposure
5. Reversal with Naloxone
IV. Treatment of Fentanyl Overdose
V. Pharmacological Profile of Fentanyl
1. Mechanism of Action and Uses of Fentanyl
2. Available Forms
3. Boxed Warning
4. Contraindications
5. Drug-drug Interactions
6. Warnings
7. Pregnancy and Breastfeeding
8. Fentanyl and Psychosis
VI. Case Study: Fentanyl Transdermal for Chronic Pain
VII. Second Case: Chronic Pain and Overdose
VIII. Summary