I. Introduction
II. Fentanyl’s Medical Uses
III. Fentanyl’s Pharmacological Effects
IV. Fentanyl’s Potential for Misuse
V. Opioid Crisis and Fentanyl Use
1. Fentanyl Use and the Opioid Crisis
2. The Opioid Crisis and COVID-19
VI. Fentanyl Overdose
1. Detection of Fentanyl
2. Patient’s History of Use
3. Patient’s Pattern of Use
4. Pediatric Exposure
5. Reversal with Naloxone
VII. Treatment of Fentanyl Overdose
1. Laboratory Testing and Physical Examination Requirements
2. Education of Opioid Overdose Treatment
VIII. Case Study: Fentanyl Transdermal for Chronic Pain
Discussion
IX. Summary