Course Summary

Cariprazine is a second-generation, atypical antipsychotic used as primary treatment for schizophrenia, and to treat manic or mixed episodes in patients who have bipolar I disorder. The following sections discuss the pharmacological profile of cariprazine, its labelled and off-label uses, warnings and precautions associated with the use of cariprazine and contraindications. These discussions are expanded in the clinical pearls section. There is a review of cariprazine overdose followed by a review of cariprazine in the case study section.

Course Format

Homestudy

Course Syllabus

• Introduction
• Pharmacological Profile
  • Mechanism of Action: Labeled and Off-label Uses
  • Dosing: Schizophrenia and Bipolar I Disorder
  • CYP3A4 Inhibitors and Inducers
  • Dosing Adjustment: Geriatric, Hepatic and Renal Impairment
  • Contraindications, Adverse Effects, and Warnings
  • Drug Interactions
  • Pregnancy and Breastfeeding
• Clinical Pearls: Cariprazine
  • Primary Treatment of Schizophrenia
  • Bipolar 1 Disorder: Manic or Mixed Episodes
  • Special Consideration for Dosing
  • Dementia-Related Psychosis
  • QT Prolongation and Cardiac Symptoms
  • EPS, Dystonia and Akathisia
  • Parkinsonism
  • Tardive Dyskinesia
  • Metabolic and GI Symptoms
  • Hyperprolactinemia
  • Neuroleptic Malignant Syndrome
  • Suicidal Ideation and Behavior
  • Pregnancy and Breastfeeding
• Cariprazine Overdose
• Research Review: Cariprazine
• Case Study: Cariprazine in Schizophrenia
• Summary

Author

Kellie Wilson, PharmD

Kellie Wilson is a Doctor of Pharmacy practicing in Anaconda, Montana, where she lives with her husband and four children. She attended the University of Montana in Missoula where she graduated in 2009 with a doctorate in pharmacy. She later worked in Boise, Idaho for a large, retail pharmacy for 2 years, and then returned home to Montana to oversee an independently owned retail and long-term care pharmacy in Anaconda. As an independent retail pharmacist she has become very involved in psychiatric pharmacy for two major behavioral health organizations that are located around all of Montana. Kellie’s passion is retail pharmacy because she enjoys the interactions with customers as well as the challenges and rewards of staying current with the continuous changes in the pharmacy field.