Duloxetine as a Treatment for Mood Disorders and Chronic Pain in Varied Patient Populations
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South Carolina Information
Pharmacotherapeutics Credits: 3
Related to prescribing controlled substances: 0
Course Summary
Duloxetine is an antidepressant that acts as a serotonin and norepinephrine reuptake inhibitor. It is approved to treat generalized anxiety disorder, chronic musculoskeletal pain, diabetic peripheral neuropathic pain, and fibromyalgia. Individuals diagnosed with chronic liver disease should avoid duloxetine treatment due to the risk of liver damage. Other warnings pertaining to the risk of suicidal thoughts in youth, pregnancy, and comorbid conditions need to be raised with patients prior to initiating treatment. An emphasis is placed on differential diagnosis and the options for treating varied patient groups with duloxetine. When deciding the dosing regimen for duloxetine during early initiation of treatment and when evaluating patient progress, consideration should be given to the patient’s age, comorbidities, and quality of life goals, in addition to any possible drug-drug interactions.
Course Format
Homestudy
Course Syllabus
- Introduction
- Pharmacological Profile, Uses, and Warnings
- Major Depressive Disorder
- Generalized Anxiety Disorder
- Chronic Musculoskeletal Pain: Osteoarthritis and Low Back
- Diabetic Peripheral Neuropathy
- Fibromyalgia
- Recommended Dosing and Dosing Adjustments
- US Boxed Warning and Contraindications
- Diagnosing Adverse Drug Reactions
- Cardiovascular
- Central Nervous System
- Dermatologic
- Endocrine
- Hyponatremia and SIADH
- Hematologic
- Gastrointestinal and Hepatic
- Urinary Hesitancy and Sexual Dysfunction
- Orthopedic
- Opthalmic
- Psychiatric
- Drug Interactions, Serotonin and Discontinuation Syndromes
- Serotonin Syndrome
- Discontinuation Syndrome
- Treatment Risks and Benefits
- Pregnancy and Breastfeeding
- Fibromyalgia
- Diabetic Peripheral Neuropathic Pain
- Neuropathic Cancer Pain
- Case Study: Duloxetine Toxicity and Hyponatremia
Differential Diagnosis and Treatment
- Summary