I. Introduction
II. Negative Pressure Wound Therapy Models
1. Filler Material
2. Foam Dressing
3. Open-weave Cotton Gauze
4. Non-woven Polyester
5. Air-tight Seal
6. Vacuum Pump
III. Negative Pressure And Tissue Healing
1. Constant Mode of Negative Pressure
2. Intermittent Use of Negative Pressure
IV. Benefits Of Vacuum-assisted Wound Closure
1. Faster Healing
2. Vascular Endothelial Growth Factor
3. Reduced Healthcare Costs
4. Pain Control
5. Surgical Site Healing
6. Lower Risk of Infection
7. Improved Blood Supply to Wound
8. Biofilm in the Wound Site
9. Incisional Negative Pressure Wound Therapy
10. Other Risks of Infection
V. Contraindications Of Negative Pressure Wound Therapy
1. Malignancy
2. Osteomyelitis
3. Non-enteric and Unexplored Fistulas
4. Necrotic Tissue with Eschar
5. Blood Vessels, Organs, Nerves and Anastomotic Site
VI. Summary