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Clostridium Difficile

Author: Noah H. Carpenter, MD

CE: 2.5 hours Pharmacology: 0.5 hour
Rated 4.7 out of 5.0 based on 19038 reviews

Course Summary

Clostridium difficile infection is a major cause of infectious disease concern in the North America. It is associated with hospital-acquired intestinal inflammation and diarrhea and, most commonly, with normal intestinal flora disruption due to poor prescribing practices of antibiotics. It has been reported that antibiotics prescribed in hospitals are often unnecessary or incorrect. Observing infection control recommendations and more careful antibiotic use can prevent clostridium difficile infection. The risk of clostridium difficile infection associated with antibiotic use and other contributing factors, disease recognition, treatment and prevention are discussed.

Course Format


Course Syllabus

I.              Introduction

II.           Disease Prevalence

III.         Risk Factors of Clostridium Difficile

1.   Antibiotic or Other Medication Use

2.   Nosocomial Infection

IV.          Diagnosis of Clostridium Difficile

1.   Polymerase Chain Reaction

2.   Cell Cytotoxicity Assay

3.   Sigmoidoscopy/Colonoscopy

4.   Imaging Tests

5.   Complications of CDI

V.            Symptoms of Clostridium Difficile

1.   Mild to Moderate Infection

2.   Severe Infection

VI.          Treatment of Clostridium Difficile

1.   Antibiotic Therapy

2.   Surgery

VII.       Recurrent Clostridium Difficile Infection

1.   Medical Treatment

VIII.     Prevention of CDI Transmission

1.   Surveillance

2.   Early Detection and Contact Precaution

3.   Environmental Cleaning

4.   Chlorhexidine Bathing

5.   Antibiotic Stewardship

6.   Gastric Acid Suppression

IX.          Summary


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