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Cariprazine

Author: Kellie Wilson, PharmD

CE: 2.5 hours Pharmacology: 2.5 hours
Rated 4.7 out of 5.0 based on 441 reviews

Course Summary

Cariprazine is a second-generation, atypical antipsychotic used as primary treatment for schizophrenia, and to treat manic or mixed episodes in patients who have bipolar I disorder. The following sections discuss the pharmacological profile of cariprazine, its labelled and off-label uses, warnings and precautions associated with the use of cariprazine and contraindications. These discussions are expanded in the clinical pearls section. There is a review of cariprazine overdose followed by a review of cariprazine in the case study section.

Course Format

Homestudy

Course Syllabus

I.    Introduction

II.    Pharmacological Profile

1. Mechanism of Action: Labeled and Off-label Uses
2. Dosing: Schizophrenia and Bipolar I Disorder
3. CYP3A4 Inhibitors and Inducers
4. Dosing Adjustment: Geriatric, Hepatic and Renal Impairment
5. Contraindications, Adverse Effects, and Warnings
6. Drug Interactions
7. Pregnancy and Breastfeeding

III.    Clinical Pearls: Cariprazine

1. Primary Treatment of Schizophrenia
2. Bipolar 1 Disorder: Manic or Mixed Episodes
3. Special Consideration for Dosing
4. Dementia-Related Psychosis
5. QT Prolongation and Cardiac Symptoms
6. EPS, Dystonia and Akathisia
7. Parkinsonism
8. Tardive Dyskinesia
9. Metabolic and GI Symptoms
10. Hyperprolactinemia
11. Neuroleptic Malignant Syndrome
12. Suicidal Ideation and Behavior
13. Pregnancy and Breastfeeding

IV.     Cariprazine Overdose

V.     Research Review: Cariprazine

VI.    Case Study: Cariprazine in Schizophrenia

VII.    Summary

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