I. Introduction
II. Prevalence of Cannabis Withdrawal Syndrome
III. Pharmacology of Cannabis
IV. Pharmacokinetics of Cannabis Use and Clinical Effects
V. Cannabis Withdrawal
1. Diagnosis
2. Clinical Course
VI. Risk Factors of Cannabis Withdrawal Syndrome
1. Age
2. Gender
3. Genetics
4. Psychiatric Comorbidity
5. Race/Ethnicity
VII. Symptoms of Cannabis Withdrawal Syndrome
VIII. Pharmacotherapy of Cannabis Withdrawal Syndrome
1. Cannabinoid Receptor Agonists
2. Nabiximol
3. Dronabinol
4. Lofexidine
5. Gabapentin
6. Guanfacine
IX. Psychotherapy
1. Cognitive Behavioral Therapy
2. Motivational Enhancement Therapy
3. Contingency Management
4. Multidimensional Family Therapy
5. Review of the Literature
X. Case Study: Drug-Induced Psychosis
XI. Summary