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Brexpiprazole for Treating Mood and Psychotic Disorders, and Dementia in Alzheimer’s Disease

Author: Richard "Cole" Daniels, PharmD, BCPS

CE: 2 hours Pharmacology: 2 hours
Rated 4.7 out of 5.0 based on 1844 reviews

Course Summary

Brexpiprazole is an atypical, second-generation antipsychotic primarily used to treat adults with schizophrenia, a mental disorder characterized by hallucinations, delusions, and disorganized thinking. It is also approved for the adjunctive treatment of major depressive disorder (MDD) in adults, which means it can be used alongside an antidepressant to enhance its effects. Certain medical conditions, such as liver impairment or a history of seizures, may require dosage adjustments or monitoring. Brexpiprazole may also increase the risk of suicidal thoughts or behavior, particularly in younger individuals with major depressive disorder.

Course Format


Course Syllabus

  1. Introduction
  1. Pharmacological Profile, Dosing and Uses
  1. Major Depressive Disorder
  2. Schizophrenia
  3. Dementia due to Alzheimer's Disease
  4. CYP2D6 Poor Metabolizers and CYP2D6 or CYP3A4 Inhibitors
  5. Dosing Adjustments: Geriatric, Hepatic and Renal
  1. Adverse Events, Contraindications and Warnings
  1. Special Patient Populations
  2. Suicidal Behavior and Ideation
  1. Precautions and Potential Clinical Complications
  1. Cardiovascular
  2. Central Nervous System
  3. Dyslipidemia
  4. Gastrointestinal
  5. Weight Gain
  6. Hyperglycemia
  7. Hematologic
  8. Neuroleptic Malignant Syndrome
  9. Temperature Regulation
  10. Seizure Disorder
  11. Hyperprolactinemia
  1. Drug Interactions and Overdose with Brexpiprazole Use
  1. Case Study: Brexpiprazole-Aripiprazole Combination Therapy
  1. Summary


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