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Author: Dana Bartlett, BSN, MSN, MA, CSPI
(Click author's name for bio)

CE: 2.5 hours Pharmacology: 2.5 hours
Rated 4.7 out of 5.0 based on 974 reviews

Course Summary

Brexpiprazole (Rexulti®) is an atypical, second-generation antipsychotic that is used as an adjunctive therapy along with antidepressants to treat major depressive disorder. Antipsychotics are the first-choice drug for acute and maintenance treatment of schizophrenia, and brexpiprazole is considered primary treatment for schizophrenia. Brexpiprazole is not approved for use in pediatric patients. The pharmacological profile of brexpiprazole, its labelled and off-label uses, contraindications, warnings and precautions associated with the use of brexpiprazole is discussed, as well as a review of brexpiprazole overdose and a case study.

Course Format


Course Syllabus

I. Introduction

II. Pharmacological Profile
1.   Category
2.   Mechanism of Action
3.   Labeled Uses
4.   Unlabeled Uses
5.   Dosing
6.   Dosing Adjustment: Geriatric Patients
7.   Dosing Adjustment: Hepatic Impairment
8.   Dosing Adjustment: Renal Impairment
9.   Available Forms
10.        US Boxed Warning
11.        Contraindications
12.        Adverse Effects
13.        Warnings and Precautions
14.        Drug Interactions
15.        Pregnancy and Breastfeeding

III. Clinical Pearls: Brexpiprazole

IV. Brexpiprazole Overdose

V. A Review: Brexpiprazole

VI. Summary


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