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Blood Transfusions: An Overview

Author: Jassin M. Jouria, MD
(Click author's name for bio)

CE: 3 hours
Rated 4.7 out of 5.0 based on 2918 reviews

Course Summary

Being able to replace blood and blood components that a patient has lost or that his or her body is not able to produce is a vital part of providing excellent medical care. With the aid of donor blood, or even sometimes the patient’s own blood that has been previously banked, medical professionals have a safe strategy for treatment of patients who have lost blood to illness or injury. This course will explain the different types of blood products, the requirements for performing a transfusion, and how to recognize and respond to complications of the transfusion process.

Course Format


Course Syllabus

  1. Introduction
  2. Overview Of Transfusions Of Blood And Blood Components
  3. Current Guidelines For Packed Red Blood Cell Transfusion
    1. Proper Uses of Red Blood Cell (RBC) Transfusion
    2. Dosage and Administration
    3. Special Processing Requirements of RBC for Transfusions
    4. When is Packed RBC Transfusion Required?
    5. When is an Other Blood Component Required?
      1. Platelets
      2. Fresh Frozen Plasma I
  4. Basic Principles Of Blood Transfusions And Pre-Transfusion Testing
    1. Donor Requirements
    2. Current Guidelines for Pre-Transfusion Testing
    3. Blood and Blood Component Pre-Testing
  5. Overview Of ABO Inheritance
    1. ABO System
    2. Rh System
  6. Overview Of Whole Blood Compatibility
    1. Pre-Transfusion Testing
      1. Donor Blood
      2. Recipient Testing
  7. Current Guidelines For Pre-Transfusion Testing Of Recipient Samples
  8. Whole Blood And Blood Components For Transfusion
    1. Packed Red Blood Cells (RBCs)
    2. White Blood Cells (WBCs)
    3. Platelet Rich Plasma (PRP)
    4. Fresh Frozen Plasma (FFP)
    5. Cryoprecipitate
    6. Immune Globulins
    7. Other Components
    8. Transfusion Techniques
    9. Observation of the Transfusion Patient
  9. Specific Indications For Blood Transfusions
    1. Injury
    2. Chronic Hemorrhage
    3. Traumatic Hemolytic Anemia
    4. Illness Due to Deficient Erythropoiesis
  10. Complications Of Transfusions: Part I
    1. Acute Hemolytic Transfusion Reactions (AHTR)
    2. Delayed Hemolytic Transfusion Reactions
    3. Acute Respiratory Distress and Lung Damage
    4. Circulatory (Volume) Overload
    5. Other Transfusion Reactions
      1. Altered Oxygen Affinity
      2. Graft-Versus-Host Disease
      3. Complications of Massive Transfusions
    6. Infections Resulting from Transfusions
      1. Bacterial Infections
      2. Viral Infections
      3. Prion Disease and Malaria
  11. Therapeutic Apheresis
    1. Plasma Exchange
    2. Cytapheresis
  12. Intrauterine Fetal Blood Transfusion: Rh Disease (Erythroblastosis Fetalis)
    1. Rh Blood Group System
  13. Complications Involved In Blood Transfusion: Part II
    1. Immediate Reactions
    2. Delayed Reactions
  14. Known Risk Factors For Transfusion Reactions
    1. Transfusion-Related Acute Lung Injury (TRALI)
    2. Transfusion Associated Circulatory Overload (TACO)
    3. Acute Kidney Injury (AKI)
    4. Rifle and Akin Criteria for Acute Kidney Injury
    5. End Stage Kidney/Renal Disease (ESK/RD)
      1. Kidney Disease Improving Global Outcomes (KDIGO) Clinical Practice Guidelines
    6. Disseminated Intravascular Coagulation (DIC)
  15. Massive Transfusions
    1. RBC Transfusion and Sepsis
    2. Infection, Prevention and Source Control
    3. Transfusion-Associated Graft-Versus-Host Disease
    4. Hypotension: Ace Inhibitors
    5. Step-By-Step Procedure For A Suspected Transfusion Reaction
  16. General Guidelines For The Transfusion Procedure
    1. Evidence Based Guidelines for the Transfusion Procedure
    2. Step-By-Step Guidelines
      1. Pre-Transfusion
      2. Obtaining Components from the Blood Bank
      3. Mislabeling
      4. Preparing the Patient for Transfusion
    3. Blood Tubing
    4. Blood or Components: Five Rights of Transfusion
    5. Starting the Transfusion
    6. Required Documentation
  17. Acute Transfusion Reactions
    1. Signs and Symptoms of an Acute Transfusion Reaction
    2. Guidelines for Continuing Transfusion if Reaction Occurs
  18. Summary


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