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Angiotensin-Converting Enzyme (ACE) Inhibitors

Author: Dana Bartlett, BSN, MSN, MA, CSPI
(Click author's name for bio)

CE: 2.5 hours Pharmacology: 2.5 hours
Rated 4.7 out of 5.0 based on 3836 reviews

Course Summary

The class of angiotensin converting enzyme (ACE) inhibitors are widely prescribed for conditions of primary hypertension. Hypertension is a very common disease that affects approximately 75 million Americans or roughly 1 in 3 adults. ACE inhibitors also have distinct, specific advantages for treating hypertensive patients who have chronic kidney disease, diabetes mellitus, heart failure, and myocardial infarction. They are known to prevent mortality related to a cardiovascular event. Except for captopril and lisinopril, the ACE inhibitors are pro-drugs, changed in the liver to a pharmacologically active metabolite. ACE inhibitors may differ in their pharmacokinetic properties, such as peak blood levels and effect on blood pressure depending on the drug.

Course Format


Course Syllabus

I.              Introduction
II.            ACE Inhibitors And The Renin-Angiotensin System
III.          Pharmacological Profile Of ACE Inhibitors
1.   Pharmacological Category
2.   Uses
3.   US Boxed Warnings
4.   Contraindications
5.   Warnings
6.   Adverse Reactions
7.   Use in Pregnancy
8.   Breastfeeding
9.   Drug-drug Interactions
10.        Dietary Considerations
11.        Pharmacodynamics
12.        Monitoring During Drug Therapy
IV.          ACE Inhibitors For Hypertension
1.   Primary Hypertension
2.   Comorbid Hypertension/Chronic Kidney Disease
V.             ACE Inhibitors For Heart Failure With Reduced Ejection Fraction
VI.          ACE Inhibitors In ST Segment Elevation Myocardial Infarction
VII.        Diabetic Nephropathy And ACE Inhibitor Use
VIII.      ACE Inhibitor-Induced Angioedema
1.   Statistics and Clinical Presentation
2.   Treatment of Angioedema
IX.          ACE Inhibitor Overdose
1.   Clinical Presentation
2.   Treatment
X.             Summary


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