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Acetaminophen Poisoning: A Comprehensive Review

Author: Dana Bartlett, BSN, MSN, MA, CSPI
(Click author's name for bio)

CE: 3.5 hours Pharmacology: 1 hour
Rated 4.6 out of 5.0 based on 4621 reviews

Course Summary

Acetaminophen toxicity is the most common cause of acute liver failure in the United States, Europe, and Australia. Liver damage after acetaminophen overdose is common but liver failure and death are rare. There is a highly effective antidote available, N-acetylcysteine, and if treated promptly, patient recovery and survival from acetaminophen toxic overdose is almost assured.

Course Format


Course Syllabus

I.            Introduction

II.         Acetaminophen Pharmacology

III.       Acetaminophen Toxicity

IV.        The Toxic Process Of Acetaminophen Poisoning And Liver Damage

V.          Clinical Presentation Of Acetaminophen Overdose

VI.        High Risk Patients For Acetaminophen Poisoning

VII.      Acute Acetaminophen Overdose And Deciding Treatment

VIII.    Initial Care For Acetaminophen Overdose

IX.        Antedotal Therapy: N-Acetylcysteine

1.   Oral NAC

2.   Intravenous NAC

X.          Chronic Ingestion Of Excess Acetaminophen

1.   Pregnancy and Acetaminophen Overdose

2.   Liver Failure and Transplantation

XI.        Summary


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