Acetaminophen Poisoning: A Comprehensive Review
In toxic overdosing, acetaminophen can cause liver damage and failure, and can lead to costly medical treatment and transplantation. Health teams need to understand the basis for diagnosis and treatment of acetaminophen overdose, which includes clinical manifestations of toxicity and use of the Rumack-Matthew nomogram to interpret acetaminophen plasma concentrations. This course will help nurses identify patients at risk of liver damage and failure due to acetaminophen toxic overdose and to know the appropriate treatment to support full recovery and survival.
- Acetaminophen Pharmacology
- Dosing, available forms, contraindications, side effects, and drug-drug interactions
- Acetaminophen Toxicity
- Toxic dose level
- Is the therapeutic dose toxic?
- The Toxic Process Of Acetaminophen Poisoning And Liver Damage
- Signs And Symptoms Of Acetaminophen Overdose
- Hepatic damage
- Renal damage
- Other organ damage
- Risk Factors For Acetaminophen Poisoning
- Children and acetaminophen: is there less risk?
- Acetaminophen Acute Overdose And Patient Treatment
- Deciding at-risk patients
- Acetaminophen serum level
- Rumack-Matthew nomogram
- Laboratory tests
- Signs and symptoms
- Initial care: stabilization and treatment
- Physical exam
- Serum acetaminophen level
- Antidotal therapy: n-acetylcysteine (NAC)
- NAC: oral versus IV
- Chronic Ingestions Of Excess Acetaminophen
- Liver Failure And Transplantation
- Pregnancy And Acetaminophen Overdose
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The author, planning committee, and reviewers have no financial or other conflicts of interest related to this course. There is no sponsorship or commercial support used for this course.
There is no "off label" usage of drugs or products discussed in this course.
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